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Room 3 – Industry Stream, brought to you by Boehringer Ingelheim Animal Health

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Session Program
6:00 pm
 | Development of in-feedlot diagnostics for the accurate and timely identification of pathogens associated with bovine respiratory disease complex (BRDC) presents specific challenges due to the necessary logistics of feedlot practice and animal management. Staff ratios associated with intensive beef production, coupled with the requirement for minimum interventions, means that a point-of-decision diagnostic must be fast, accurate and reliable but also inexpensive to be useful and effective in improving animal outcomes as well as making a meaningful impact on economic margins at induction. Necessary minimisation of pulls for intervention and / or treatment equally presents a challenge for diagnosis and management of BRDC-affected animals in the hospital system, who rarely undergo detailed diagnostic workup. To be an effective strategy for the in-feedlot analysis of the major bacterial pathogens associated with bovine respiratory disease complex, the timeline for sampling and results must fit within existing feedlot workflows to be adopted by industry. A co-design approach was undertaken to develop an in-feedlot diagnostic tool capable of informing BRDC management decisions which will be discussed. This approach is based on quantitative PCR with increased accuracy of the results and will also be highlighted using analysis of induction and hospital pen cattle from two commercial feedlots in Australia.
6:15 pm
Perennial Ryegrass Toxicosis (PRGT) is a clinical syndrome of herbivores in southern regions of Australia and New Zealand grazing pasture with a high proportion of perennial ryegrass. To date no clinically applicable therapeutic has been available to treat clinical cases of PRGT or to prevent disease.   PRGT is a complex toxicity with multiple alkaloids involved. Disease presentations range from subclinical productivity losses to a severe neurological syndrome with ataxia, tremor, recumbency and occasionally death. Lolitrem B, the primary toxin responsible for neurological signs, is thought to block calcium activated potassium channels (BK Channels). In the brain this will have a number of effects; generally it will increase neuronal instability. In the cerebellum however the overall effect is to reduce neuronal outputs. As the cerebellum is involved in regulating movement the effect of intoxication is for movement to become less regulated and more exaggerated (cerebellar ataxia) or the classical “ryegrass staggers” presentation.  This presentation considers the use of bromide, an accepted therapy for epilepsy in small animals and humans, as a treatment for PRGT and evaluates therapeutic efficacy within murine and ovine models of Perennial Ryegrass Toxicosis (PRGT).  Trials demonstrate that bromide is effective at reducing lolitrem B induced tremor and ataxia. Because of its limited side effects, high oral bioavailability, high safety margin and low cost, bromide is a good potential on-farm therapy for PRGT.
6:30 pm
The gastrointestinal (GI) microbiome refers to the ecosystem consisting of billions of microorganisms that live within an individual’s gastrointestinal tract. 
 
 Soluble prebiotic dietary fibres are an important substrate for the colonic bacteria within the GI microbiome. They are metabolised to form end products including short-chain fatty-acids (SCFA) and antioxidant and anti-inflammatory-rich polyphenols; many of which can be beneficial for the host.
 
 Nutrition has the ability to use the power of the pet’s own GI microbiome to support digestive health, and because dogs and cats have to eat every day, choosing complete and balanced foods specifically designed to promote digestive health is the most practical and lasting strategy to positively influence the GI microbiome.
 
 This lecture will discuss ground-breaking new research highlighting the critical role nutrition can play for a dog’s GI microbiome - not only for GI disease, but also for overall health and well-being.
6:45 pm
Malaria, African trypanosomosis, Chagas disease, Leishmaniosis, Toxoplasmosis and Cryptosporidiosis in humans and infection of animals with Eimeria, Cystoisospora, Giardia and Babesia are the globally most important protozoal diseases.  Antiprotozoal resistance, low efficacy and adverse effects are all potential important limitations of currently available therapeutic agents.  A novel agent with unique mode of action is a critical need and is the subject of this project.

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