Applying general principles of decontamination (gastrointestinal and/or skin) can be lifesaving in the recently intoxicated small animal patient. The role of antidotes is quite restricted to a minority of toxins, hence in most cases of overdose, survival is crucially dependent on supportive care. Further, antidotes to toxins do not negate the necessity for decontamination in many intoxications. Knowledge of the pathophysiology, toxic doses of, and treatments prepares the clinician to deal with the emergency poisoned pet and ready access to the materials and medicaments for decontamination, antidotal and supportive therapy is paramount in providing medical care for toxin cases. Rapid access to details of unfamiliar toxins helps direct further management of the emergency. A veterinary practice ‘toolbox’ for intoxications includes antivenenes against possible arachnid and elapid envenomations, known antidotes for likely common and uncommon intoxications, current recommended medicants for emesis and decontamination, and remedies for supportive care and management of symptoms and potential adverse effects. This presentation will highlight the contents of a typical practice toolbox for treating canine and feline intoxications.