This presentation will outline the current challenges with equine parasite control and discuss approaches for parasite control. Global levels of anthelmintic resistance are ever-increasing in strongylid and ascarid parasites, and the pharmaceutical industry has not developed and introduced any new anthelmintic classes since ivermectin 40 years ago. Combination deworming is not a solution for already developed resistance despite often made claims. All active ingredients are losing anthelmintic spectrum and the good old all-round dewormer no longer exists. The consequence of this is an increasing need for diagnostic surveillance and more emphasis on developing better and more refined diagnostic tools.