Pre-anaesthetic blood testing is pretty much a part of practice now. It is critical that veterinarians have a “game plan” for addressing the potential issues being presented by the identification of abnormal blood tests. During this session we will be discussing when and how I go about investigating abnormal hepatic enzyme parameters on Pre-anaesthetic blood testing. Both history taking and a thorough physical examination should be standard in every patient. Depending on the clinical and historical findings, and abnormalities identified on the Pre-anaesthetic blood testing, different pathways may be indicated in further investigation. This may be simply “monitoring” both the patient and biochemistry, or it may involve a LDDST or ACTH Stimulation Test, or pre and postprandial bile acid testing, abdominal ultrasound or tissue sampling by cytology or the collection of biopsies.