|In 2018, a unique strain of Salmonella Enteriditis (SE) was detected in humans and was traced back to a NSW egg farm. Over a course of two years, 16 egg layer properties in NSW and 2 in Victoria were identified as infected and were managed through strict biosecurity controls, movement restrictions, culling and decontamination. All properties in NSW were linked through movement of eggs, people or equipment. There have been 8 food recalls and 3 withdrawals of eggs and approximately 300 human SE cases nationally. The management of the SE outbreak has highlighted the importance of a One Health approach with Food Safety, human and animal health and poultry industry working closely together. The impact of the outbreak has led to significant changes including improvement in biosecurity , changes to regulation and new ways of doing business.